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A patients genome gives a physician a whole new insight into the way he/she will evaluate and ultimately diagnose their patient. The genome gives a basic background into the patient.  This gives a physician the ability to see the way their body functions, how it will react, and traits they posses.  Before any treatment is done a physician can have a clear plan into the route of many disease the patient may, or potentially could have.  It gives the doctor the ability to know what genes the patient is carrying, and the way the patient would respond to different pharmaceuticals.  This information gives a physician a new insight into the way they can prevent and correctly diagnose a patient.

Preventative medicine is a very vast and rapid growing industry.  A patients genome gives a physician a whole new aspect on the way they can prevent developing of many diseases a patient could be prone to. This can all be done through many measures like taking supplements, vitamins, and dieting effectively to Simple workout regiments and learning exercises. By adding these factors a patient can actually turn on or express genes that are beneficial to their health. In addition genes that promote negative signals like high LDL cholesterol can be turned off or unexpressed.

This is done through micronutrients, macronutrients, and certain pharmaceuticals designed to alter DNA in specific ways.  These substances are able to stimulate a cell to turn off or a certain genes within the patients DNA.  This is done through many processes. We will focus on most familiar two: phosphorylation and methylation.  Think of it as phosphorylation turns on certain genes and methylation can turn off certain genes.  This is done through coiling and uncoiling DNA to allow or disallow the DNA strand to be transcribed.  DNA is tightly wrapped around large proteins know as histones.  These histones help condense the DNA to a small enough size that allows it to fit into the cell.  If DNA did not go through the process of supercoiling and wrapping around histones it would be about three meters in length.  Once DNA is wrapped around the protein histones it is inaccessible to be transcribed.  In order for the cell to survive it must unwrap certain areas of DNA from the histones in order to be transcribed.  This is done through phosphorylation thus turning on the gene, allowing it to be read.  Methylation works in a similar but opposite way by tightly coiling certain areas of DNA or turning off this area of DNA. This tight compaction makes the DNA inaccessible for transcription.  Both phosphorylation and methylation can be achieved by proper diet, hormone balance, pharmaceuticals, and maintaining a balanced and healthy way of life. Once the genes are found, it is as simple as creating an environment (aka your body’s internal chemistry) that is beneficial to promoting a healthy lifestyle for human cells by helping turn certain genes on and off.

The remainder of this book will look into new ways to use your genome to create a custom and effective health plan for patients.  First we will look into the ways nutrition and supplements can help stabilize your health all the way down to the genetic level.  Second the use of hormone replacement is very essential in maintaining certain genes that code for very essential proteins.  Third we will look into the way the pharmaceutical world is co-evolving with the new insight of how to manipulate your genetic codes rather than just mask symptoms.  Last we will look into what the future has in store for newer and more promising ways to help maintain health through genomic clues.



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